Mark Sostek Selected Research

Therapeutics

1/2018	Cardiovascular Safety of the Selective μ-Opioid Receptor Antagonist Naloxegol: A Novel Therapy for Opioid-Induced Constipation.
11/2015	Safety, tolerability, and pharmacokinetics of multiple ascending doses of naloxegol.
7/2014	Description of cardiovascular event rates in patients initiating chronic opioid therapy for noncancer pain in observational cohort studies in the US, UK, and Germany.
1/2006	Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trial.

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Mark Sostek Research Topics

Disease

14	Opioid-Induced Constipation 01/2018 - 09/2013
11	Pain (Aches) 01/2018 - 01/2006
4	Chronic Pain 01/2018 - 11/2015
2	Miosis 04/2016 - 11/2015
2	Cancer Pain 10/2015 - 03/2015
1	Colonic Neoplasms (Colon Cancer) 01/2017
1	Constipation 10/2015
1	Neoplasms (Cancer) 03/2015
1	Chronic Kidney Failure (Chronic Renal Failure) 12/2014
1	Knee Osteoarthritis 06/2011
1	Osteoarthritis 06/2011
1	Heartburn (Pyrosis) 01/2006
1	Gastroesophageal Reflux (GERD) 12/2003

Drug/Important Bio-Agent (IBA)

11	Opioid Analgesics (Opioids)IBA 01/2018 - 09/2013
11	naloxegolIBA 01/2018 - 09/2013
8	Narcotic Antagonists (Opioid Antagonists)IBA 01/2018 - 09/2013
3	Esomeprazole (Nexium)FDA Link 06/2011 - 12/2003
2	Naloxone (Narcan)FDA LinkGeneric 01/2017 - 01/2016
2	Morphine (MS Contin)FDA LinkGeneric 04/2016 - 11/2015
2	Lansoprazole (Prevacid)FDA LinkGeneric 01/2006 - 12/2003
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2017
1	Opioid Receptors (Opioid Receptor)IBA 01/2017
1	Quinidine (Chinidin)FDA LinkGeneric 04/2016
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2016
1	LaxativesIBA 10/2015
1	PolymersIBA 09/2013
1	Celecoxib (Celebrex)FDA Link 06/2011
1	Naproxen (Naprosyn)FDA LinkGeneric 06/2011
1	Prostaglandins AIBA 06/2011
1	AntacidsIBA 01/2006
1	TabletsIBA 01/2006
1	Proton Pump InhibitorsIBA 01/2006
1	AcidsIBA 01/2006
1	Rabeprazole (Aciphex)FDA Link 12/2003
1	Omeprazole (Prilosec)FDA LinkGeneric 12/2003
1	Pantoprazole (Protonix)FDA LinkGeneric 12/2003

Therapy/Procedure

4	Therapeutics 01/2018 - 01/2006
2	Analgesia 01/2018 - 01/2017
1	Drug Therapy (Chemotherapy) 01/2017